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National Institute of Allergy and Infectious Disease
NIH 3D
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NIH3D

Hth-01-015

PubChem 78357766
was used by NIH 3D workflows to automatically generate models for
Daniel Navarrete
Created:
9/27/25
Submitted:
10/7/26
Published:
10/7/26
ball-and-stick, color, print caution
78357766-bas-color-print_cautionAtoms shown as ball-and-stick (geometry appears faceted on screen; apply smooth normals in Blender or similar to improve visualization; generally smooth when 3D printed) with standard colors. 3D printable, with caution, using certain 3D printers.

Select an image below to view

ball-and-stick, color, print cautionball-and-stick, no color, NIH 3D repairedthin sticks, colorthin sticks, no colorthick sticks, color, print cautionthick sticks, no color, NIH 3D repairedspace-filled, color, print cautionspace-filled, no color, NIH 3D repaired

Learn more about NIH 3D workflow outputs

3DPX-022966

NIH 3D DOI:

https://doi.org/10.60705/3dpx/22966.2

Licensing:

CC-BY
How to cite this NIH 3D entry
190
66
Version 2

Category

Small Molecules
Small Molecules
Description
HTH-01-015 is an organic heterotetracyclic compound that is 5,13-dihydro-6H-naphtho[2,3-e]pyrimido[5,4-b][1,4]diazepin-6-one substituted by methyl groups at positions 4, 5 and 13, and by a [1-(piperidin-4-yl)-1H-pyrazol-4-yl]amino group at position 2. It is a potent NUAK1 inhibitor (IC50 = 100 nM). It has a role as an EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor. It is a member of piperidines, a member of pyrazoles, an aromatic amine, an organic heterotetracyclic compound, a secondary amino compound and a tertiary amino compound.
Source Data Details
https://pubchem.ncbi.nlm.nih.gov/image/imagefly.cgi?cid=78357766&width=400&height=400