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National Institute of Allergy and Infectious Disease
NIH 3D
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NIH3D

Voltage-dependent L-type calcium channel subunit alpha-1S

Generated by NIH 3D workflows using data provided by
cass condray
Created:
6/21/25
Submitted:
6/21/25
Published:
6/21/25
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3DPX-022494

Licensing:

CC-BY
How to cite this NIH 3D entry
22
0
Version 1

Category

Biomacromolecules
Biomacromolecules
Description

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, gene expression, cell motility, cell division and cell death. The isoform alpha-1S gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, and by benzothiazepines. Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skele|tal muscle (By similarity)

Source Data Details