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National Institute of Allergy and Infectious Disease
NIH 3D
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NIH3D

HIV-1 TAR RNA/NEOMYCIN B COMPLEX

Generated by NIH 3D workflows using data provided by
cass condray
Created:
6/21/25
Submitted:
6/20/25
Published:
6/21/25
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3DPX-022174

Licensing:

CC-BY
How to cite this NIH 3D entry
11
0
Version 1

Category

Biomacromolecules
Biomacromolecules
Description

Binding of human immunodeficiency virus type 1 (HIV-1) transactivator (Tat) protein to Tat-responsive RNA (TAR) is essential for viral replication and is considered a promising starting point for the design of anti-HIV drugs. NMR spectroscopy indicated that the aminoglycosides neomycin B and ribostamycin bind to TAR and that neomycin is able to inhibit Tat binding to TAR. 

Source Data Details