Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock () or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

National Institute of Allergy and Infectious Disease
NIH 3D
FAQsBioArt

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock () or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

NIH3D

Axin1

Generated by NIH 3D workflows using data provided by
Jeff Miller
Created:
5/16/25
Submitted:
5/11/25
Published:
5/16/25
ribbon , colored by secondary structure, not intended for 3D printing
AF-O70239-F1-model_v4-ribbon-secondary-vis_NIH3DRibbon representation colored by secondary structure (a-helix: blue, B-sheet: red, coil: yellow). Not intended for 3D Printing

Select an image below to view

ribbon , colored by secondary structure, not intended for 3D printingribbon , colored by rainbow, not intended for 3D printingribbon , colored by by chain, not intended for 3D printingribbon , not intended for 3D printingribbon , colored by secondary structure, print cautionribbon , colored by rainbow, print cautionribbon , colored by by chain, print cautionribbon , repaired for 3D printingribbon , print caution

surface, colored by by chain, not intended for 3D printingsurface, colored by hydrophobicity, not intended for 3D printingsurface, colored by local charge, not intended for 3D printingsurface, not intended for 3D printingsurface, colored by by chain, print cautionsurface, colored by hydrophobicity, print cautionsurface, colored by local charge, print cautionsurface, print caution
3DPX-021928

Licensing:

Public Domain
How to cite this NIH 3D entry
28
1
Version 1

Category

Biomacromolecules
Biomacromolecules
Description

Axin1 is a key protein involved in the regulation of canonical Wnt signaling and tumor suppression. It acts as a scaffold protein, facilitating the formation of the β-catenin destruction complex which inhibits Wnt signaling. Axin1 is a core component of the destruction complex, which targets β-catenin for degradation through phosphorylation and ubiquitination. By promoting β-catenin degradation, Axin1 inhibits the canonical Wnt pathway, which is a crucial pathway for cell growth and development. Axin1 interacts with other proteins involved in Wnt signaling, such as APC, GSK3β, and LRP5/6.



Source Data Details