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National Institute of Allergy and Infectious Disease
NIH 3D
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NIH3D

Axin1

Generated by NIH 3D workflows using data provided by
Jeff Miller
Created:
5/16/25
Submitted:
10/9/26
Published:
10/9/26
AlphaFold model of Axin1. thin ribbon, secondary structure
af-o70239-f1-model_v4-ribbon-thin-secondaryAlphaFold model of Axin1. Thin ribbon representation colored by secondary structure (a-helix: blue, B-sheet: red, coil: yellow).

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AlphaFold model of Axin1. thin ribbon, secondary structureAlphaFold model of Axin1. thin ribbon, rainbowAlphaFold model of Axin1. thin ribbon, by chainAlphaFold model of Axin1. thin ribbon, no colorAlphaFold model of Axin1. thick ribbon, secondary structure, print cautionAlphaFold model of Axin1. thick ribbon, rainbow, print cautionAlphaFold model of Axin1. thick ribbon, by chain, print cautionAlphaFold model of Axin1. thick ribbon, no color, NIH 3D repaired

AlphaFold model of Axin1. lo-res mol surface, by chainAlphaFold model of Axin1. lo-res mol surface, hydrophobicityAlphaFold model of Axin1. lo-res mol surface, coulombicAlphaFold model of Axin1. lo-res mol surface, no colorAlphaFold model of Axin1. hi-res mol surface, by chain, print cautionAlphaFold model of Axin1. hi-res mol surface, hydrophobicity, print cautionAlphaFold model of Axin1. hi-res mol surface, coulombic, print cautionAlphaFold model of Axin1. hi-res mol surface, no color, print caution

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3DPX-021928

Licensing:

Public Domain
How to cite this NIH 3D entry
146
57
Version 2

Category

Biomacromolecules
Biomacromolecules
Description

Axin1 is a key protein involved in the regulation of canonical Wnt signaling and tumor suppression. It acts as a scaffold protein, facilitating the formation of the Î²-catenin destruction complex which inhibits Wnt signaling. Axin1 is a core component of the destruction complex, which targets β-catenin for degradation through phosphorylation and ubiquitination. By promoting β-catenin degradation, Axin1 inhibits the canonical Wnt pathway, which is a crucial pathway for cell growth and development. Axin1 interacts with other proteins involved in Wnt signaling, such as APC, GSK3β, and LRP5/6.



Source Data Details