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National Institute of Allergy and Infectious Disease
NIH 3D
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NIH3D

KRAS

Generated by NIH 3D workflows using data provided by
Jeff Miller
Created:
5/16/25
Submitted:
5/11/25
Published:
5/16/25
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3DPX-021926

Licensing:

Public Domain
How to cite this NIH 3D entry
71
3
Version 1

Category

Biomacromolecules
Biomacromolecules
Description

The KRAS protein acts as a molecular switch, regulating cell growth and division. It cycles between active (GTP-bound) and inactive (GDP-bound) states. oOncogenic mutations, can cause KRAS to become permanently stuck in the active state, leading to excessive signaling and uncontrolled cell growth. Mutated KRAS activates various downstream signaling pathways, including the RAF-MEK-ERK and PI3K-AKT-mTOR pathways, which promote cell proliferation, survival, and growth.




Source Data Details