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National Institute of Allergy and Infectious Disease
NIH 3D
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NIH3D

BAX apoptosis regulator

Generated by NIH 3D workflows using data provided by
Jeff Miller
Created:
5/16/25
Submitted:
5/10/25
Published:
5/16/25
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3DPX-021922

Licensing:

Public Domain
How to cite this NIH 3D entry
43
2
Version 1

Category

Biomacromolecules
Biomacromolecules
Description

BAX plays a role in the mitochondrial apoptotic process. Under normal conditions, BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol mediated by BCL2L1/Bcl-xL, which avoids accumulation of toxic BAX levels at the mitochondrial outer membrane (MOM). Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis

Source Data Details