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National Institute of Allergy and Infectious Disease
NIH 3D
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NIH3D

diketopiperazine DL isomerase

Generated by NIH 3D workflows using data provided by
AmyLane
Created:
2/13/25
Submitted:
2/12/25
Published:
2/13/25
ribbon , colored by secondary structure, not intended for 3D printing
Supplementary Data NozR with LLcWW-ribbon-secondary-vis_NIH3DRibbon representation colored by secondary structure (a-helix: blue, B-sheet: red, coil: yellow). Not intended for 3D Printing

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3DPX-021722

Licensing:

CC-BY
How to cite this NIH 3D entry
57
1
Version 1

Category

Biomacromolecules
Biomacromolecules
Description

This is a molecular model of stereoisomerase NozR docked with substrate cyclo-L-Trp-L-Trp. NozR catalyzes the reversible interconversion of D/L stereoisomers of diketopiperazines (DKPs), including cyclo-L-Trp-L-Trp. NozR is an enzyme from the nocardioazine biosynthetic pathway from actinomycete Nocardiopsis sp. CMB-M0232.


NozR and this molecular model were first published in: Deletti G, Green SD, Weber C, Patterson KN, Joshi SS, Khopade TM, Coban M, Veek-Wilson J, Caulfield T, Viswanathan R, Lane AL. (2023) Unveiling an indole alkaloid diketopiperazine biosynthetic pathway that features a unique stereoisomerase and multifunctional methyltransferase. Nature Communications. 14: 2558


Source Data Details