Isocycloseram is a diastereoisomeric mixture containing containing 80-100% of the (4R,5S)-isomer and 0-20% of (4R,5R)-,(4S,5R)-, and (4S,5S)-isomers. It is a broad-spectrum insecticide and acaricide developed by Syngenta Crop Protection that is active against several pest species including lepidopteran, hemipteran, and dipteran pest species. It has a role as an insecticide, an acaricide, a GABA-gated chloride channel antagonist and an agrochemical. It contains a (4R,5S)-isocycloseram, a (4R,5R)-isocycloseram, a (4S,5R)-isocycloseram and a (4S,5S)-isocycloseram.