Hepatitis B Relaxed Circular DNA, condensed (PathogenAR)
Created by
kbrowne
Created:
7/23/21
Submitted:
10/8/26
Published:
10/8/26
Category
Collection(s)
Description
This model approximates RC DNA when folded inside the capsid.
The RC DNA was built by snapping a curve path to the interior of the capsid surface in Maya, then shrinking it to provide some extra space. ~3200bp of DNA was then created along the path using Molecular Maya's dsDNA Rigging Kit (https://clarafi.com/training/intro-mmaya-dsdna-kit). RT from HIV was used as a very general approximation of P Protein as a structure was not available. PDB 1T03</color> was fitted to the RC DNA and bases were removed from the strand as appropriate.
This model was used in the PathogenAR Hepatitis B: The Hepatitis B Life Cycle Module in PathogenAR (https://www.niaid.nih.gov/research/pathogenar-mobile-app)
