Hepatitis B Relaxed Circular DNA, condensed (PathogenAR)
Created by
kbrowne
Created:
7/23/21
Submitted:
8/16/23
Published:
8/16/23
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Description
This model approximates RC DNA when folded inside the capsid.
The RC DNA was built by snapping a curve path to the interior of the capsid surface in Maya, then shrinking it to provide some extra space. ~3200bp of DNA was then created along the path using Molecular Maya's dsDNA Rigging Kit (https://clarafi.com/training/intro-mmaya-dsdna-kit). RT from HIV was used as a very general approximation of P Protein as a structure was not available. PDB 1T03</color> was fitted to the RC DNA and bases were removed from the strand as appropriate.
An illustration of the life cycle from PathogenAR is included, with the step associated with this model highlighted.
This model was used in the PathogenAR Hepatitis B: The Hepatitis B Life Cycle Module in PathogenAR (https://www.niaid.nih.gov/research/pathogenar-mobile-app)
