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National Institute of Allergy and Infectious Disease
NIH 3D
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NIH3D

Bisantrene

PubChem 5351322
was used by NIH 3D workflows to automatically generate models for
gscho
Created:
3/27/21
Submitted:
3/6/23
Published:
3/6/23
ball and stick, print caution
5351322-bas-color-print_NIH3DAtoms shown as ball-and-stick with standard colors. 3D printable, with caution, using certain 3D printers.

Select an image below to view

ball and stick, print cautionsticks, not intended for 3D printingsticks, not intended for 3D printingsticks, print cautionspace-filled, print cautionspace-filled, print cautionsticks, print cautionball and stick, print caution
3DPX-015595

NIH 3D DOI:

https://doi.org/10.60705/3dpx/15595.2

Licensing:

CC-BY
How to cite this NIH 3D entry
44
1
Version 2

Category

Small Molecules
Small Molecules
Description
Bisantrene is an anthracenyl bishydrazone with antineoplastic activity. Bisantrene intercalates with and disrupts the configuration of DNA, resulting in DNA single-strand breaks, DNA-protein crosslinking, and inhibition of DNA replication. This agent is similar to doxorubicin in activity, but unlike doxorubicin, does not exhibit cardiotoxicity. (NCI04)
Source Data Details
https://pubchem.ncbi.nlm.nih.gov/image/imagefly.cgi?cid=5351322&width=400&height=400
https://pubchem.ncbi.nlm.nih.gov/image/imagefly.cgi?cid=5351322&width=400&height=400