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NIH3D

Remdesivir

PubChem 121304016
was used by NIH 3D workflows to automatically generate models for
Mathew Hale
Created:
6/2/20
Submitted:
3/6/23
Published:
3/6/23

Select an image below to view

3DPX-014482

Licensing:

CC-BY
65
5
Version 2

Category

Small Molecules
Small Molecules
Description

Remdesivir is a carboxylic ester resulting from the formal condensation of the carboxy group of N-[(S)-{[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl]methoxy}(phenoxy)phosphoryl]-L-alanine with the hydroxy group of 2-ethylbutan-1-ol. A broad-spectrum antiviral prodrug with potent in vitro antiviral activity against a diverse panel of RNA viruses such as Ebola virus, MERS-CoV and SARS-CoV. It is currently in Phase III clinical trials for the treatment of Covid-19 in adults. It has a role as an antiviral drug, a prodrug and an anticoronaviral agent. It is a carboxylic ester, a pyrrolotriazine, a nitrile, a phosphoramidate ester, a C-nucleoside and an aromatic amine. It is functionally related to a GS-441524.
https://pubchem.ncbi.nlm.nih.gov/image/imagefly.cgi?cid=121304016&width=400&height=400
https://pubchem.ncbi.nlm.nih.gov/image/imagefly.cgi?cid=121304016&width=400&height=400