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NIH3D

HA Mosaic Nanoparticle - PathogenAR

Created by
kbrowne
Created:
4/2/20
Submitted:
10/8/26
Published:
10/8/26

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Learn more about NIH 3D workflow outputs

3DPX-013416

Licensing:

CC-BY
474
32
Version 5

Category

Biomacromolecules
Biomacromolecules

Collection(s)

Description

This model was created for PathogenAR, an augmented reality program being developed by the Biovisualization Program in the Bioinformatics and Computational Biosciences Branch in the Office of Cyber Infrastructure and Computational Biology at NIAID.

This structure consists of engineered protein chains that can form a small sphere (the nanoparticle), each spliced to different Hemagglutinin (HA) chains.  These spontaneously come together to form spheres, with 5 copies each of 4 different HA types projecting from its surface.  These multiple types of HA on a single vaccine particle can produce a broader immune response.