Dasatinib
Created:
2/17/19
Submitted:
10/7/26
Published:
10/7/26
3062316-bas-color-print_cautionAtoms shown as ball-and-stick (geometry appears faceted on screen; apply smooth normals in Blender or similar to improve visualization; generally smooth when 3D printed) with standard colors. 3D printable, with caution, using certain 3D printers.
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Description
Dasatinib (anhydrous) is an aminopyrimidine that is 2-methylpyrimidine which is substituted at position 4 by the primary amino group of 2-amino-1,3-thiazole-5-carboxylic acid and at position 6 by a 4-(2-hydroxyethyl)piperazin-1-yl group, and in which the carboxylic acid group has been formally condensed with 2-chloro-6-methylaniline to afford the corresponding amide. A multi-targeted kinase inhibitor, it is used, particularly as the monohydrate, for the treatment of chronic, accelerated, or myeloid or lymphoid blast phase chronic myeloid leukemia. Note that the name 'dasatinib' is used to refer to the monohydrate (USAN) as well as to anhydrous dasatinib (INN). It has a role as an anticoronaviral agent, an antineoplastic agent and a tyrosine kinase inhibitor. It is a monocarboxylic acid amide, an organochlorine compound, an aminopyrimidine, a member of 1,3-thiazoles, a N-arylpiperazine, a N-(2-hydroxyethyl)piperazine, a secondary amino compound and a tertiary amino compound. It is a conjugate base of a dasatinib(1+).
