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National Institute of Allergy and Infectious Disease
NIH 3D
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NIH3D

Dactinomycin

Generated by NIH 3D workflows using data provided by
Kzoghebi
Created:
2/17/19
Submitted:
10/6/26
Published:
10/6/26
ball-and-stick, color, print caution
dactinomycin-bas-color-print_cautionAtoms shown as ball-and-stick (geometry appears faceted on screen; apply smooth normals in Blender or similar to improve visualization; generally smooth when 3D printed) with standard colors. 3D printable, with caution, using certain 3D printers.

Select an image below to view

ball-and-stick, color, print cautionball-and-stick, no color, NIH 3D repairedthin sticks, colorthin sticks, no colorthick sticks, color, print cautionthick sticks, no color, NIH 3D repairedspace-filled, color, print cautionspace-filled, no color, NIH 3D repaired

Learn more about NIH 3D workflow outputs

3DPX-010570

Licensing:

CC-BY
How to cite this NIH 3D entry
283
17
Version 3

Category

Small Molecules
Small Molecules
Description

Dactinomycin is a chromopeptide antineoplastic antibiotic isolated from the bacterium Streptomyces parvulus. Dactinomycin intercalates between adjacent guanine-cytosine base pairs, blocking the transcription of DNA by RNA polymerase; it also causes single-strand DNA breaks, possibly via a free-radical intermediate or an interaction with topoisomerase II.

Source Data Details