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National Institute of Allergy and Infectious Disease
NIH 3D
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NIH3D

Dactinomycin

Generated by NIH 3D workflows using data provided by
Kzoghebi
Created:
2/17/19
Submitted:
3/6/23
Published:
3/6/23
ball and stick, print caution
Dactinomycin-bas-color-print_NIH3DAtoms shown as ball-and-stick with standard colors. 3D printable, with caution, using certain 3D printers.

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ball and stick, print cautionsticks, not intended for 3D printingsticks, not intended for 3D printingsticks, print cautionspace-filled, print cautionspace-filled, print cautionsticks, print cautionball and stick, print caution
3DPX-010570

Licensing:

CC-BY
How to cite this NIH 3D entry
128
8
Version 2

Category

Small Molecules
Small Molecules
Description

Dactinomycin is a chromopeptide antineoplastic antibiotic isolated from the bacterium Streptomyces parvulus. Dactinomycin intercalates between adjacent guanine-cytosine base pairs, blocking the transcription of DNA by RNA polymerase; it also causes single-strand DNA breaks, possibly via a free-radical intermediate or an interaction with topoisomerase II.

Source Data Details