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National Institute of Allergy and Infectious Disease
NIH 3D
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NIH3D

Cabazitaxel

Generated by NIH 3D workflows using data provided by
Kzoghebi
Created:
2/17/19
Submitted:
3/6/23
Published:
3/6/23
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Cabazitaxel-bas-color-print_NIH3DAtoms shown as ball-and-stick with standard colors. 3D printable, with caution, using certain 3D printers.

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3DPX-010557

Licensing:

CC-BY
How to cite this NIH 3D entry
55
4
Version 2

Category

Small Molecules
Small Molecules
Description

Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity. Cabazitaxel binds to and stabilizes tubulin, resulting in the inhibition of microtubule depolymerization and cell division, cell cycle arrest in the G2/M phase, and the inhibition of tumor cell proliferation. Unlike other taxane compounds, this agent is a poor substrate for the membrane-associated, multidrug resistance (MDR), P-glycoprotein (P-gp) efflux pump and may be useful for treating multidrug-resistant tumors. In addition, cabazitaxel penetrates the blood-brain barrier (BBB).

Source Data Details