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National Institute of Allergy and Infectious Disease
NIH 3D
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NIH3D

Triacsin C

Generated by NIH 3D workflows using data provided by
TJP355
Created:
2/1/19
Submitted:
3/6/23
Published:
3/6/23
ball and stick, print caution
Structure3D_CID_9576787-bas-color-print_NIH3DAtoms shown as ball-and-stick with standard colors. 3D printable, with caution, using certain 3D printers.

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3DPX-010461

Licensing:

CC-BY
How to cite this NIH 3D entry
36
1
Version 2

Category

Small Molecules
Small Molecules
Description

Triacsins are a family of natural products containing an N‐hydroxytriazene moiety not found in any other known secondary metabolites. Triacsin C is a potent inhibitor of long fatty acyl CoA synthetase. It blocks β-cell apoptosis, induced by fatty acids in a rat model of obesity. In addition, it blocks the de novo synthesis of triglycerides, diglycerides, and cholesterol esters, thus interfering with lipid metabolism.
https://doi.org/10.1002/cbic.201800762

Source Data Details