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National Institute of Allergy and Infectious Disease
NIH 3D
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NIH3D

Triacsin C

Generated by NIH 3D workflows using data provided by
TJP355
Created:
2/1/19
Submitted:
10/6/26
Published:
10/6/26
ball-and-stick, color, print caution
structure3d_cid_9576787-bas-color-print_cautionAtoms shown as ball-and-stick (geometry appears faceted on screen; apply smooth normals in Blender or similar to improve visualization; generally smooth when 3D printed) with standard colors. 3D printable, with caution, using certain 3D printers.

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ball-and-stick, color, print cautionball-and-stick, no color, NIH 3D repairedthin sticks, colorthin sticks, no colorthick sticks, color, print cautionthick sticks, no color, NIH 3D repairedspace-filled, color, print cautionspace-filled, no color, NIH 3D repaired

Learn more about NIH 3D workflow outputs

3DPX-010461

Licensing:

CC-BY
How to cite this NIH 3D entry
159
13
Version 3

Category

Small Molecules
Small Molecules
Description

Triacsins are a family of natural products containing an N‐hydroxytriazene moiety not found in any other known secondary metabolites. Triacsin C is a potent inhibitor of long fatty acyl CoA synthetase. It blocks β-cell apoptosis, induced by fatty acids in a rat model of obesity. In addition, it blocks the de novo synthesis of triglycerides, diglycerides, and cholesterol esters, thus interfering with lipid metabolism.
https://doi.org/10.1002/cbic.201800762

Source Data Details