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National Institute of Allergy and Infectious Disease
NIH 3D
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NIH3D

Tideglusib

PubChem 11313622
was used by NIH 3D workflows to automatically generate models for
nevitdilmen
Created:
2/19/18
Submitted:
3/6/23
Published:
3/6/23
ball and stick, print caution
11313622-bas-color-print_NIH3DAtoms shown as ball-and-stick with standard colors. 3D printable, with caution, using certain 3D printers.

Select an image below to view

ball and stick, print cautionsticks, not intended for 3D printingsticks, not intended for 3D printingsticks, print cautionspace-filled, print cautionball and stick, print cautionsticks, print cautionspace-filled, print caution
3DPX-008687

NIH 3D DOI:

https://doi.org/10.60705/3dpx/8687.2

Licensing:

CC-BY
How to cite this NIH 3D entry
83
2
Version 2

Category

Small Molecules
Small Molecules
Description
Tideglusib is a member of the class of thiadiazolidines that is 1,2,4-thiadiazolidine-3,5-dione which is substituted by a naphthalen-1-yl group at position 2 and by a benzyl group at position 4. It is a non-ATP competitive inhibitor of glycogen synthase kinase 3beta (GSK3beta) and has neuroprotective effects. Currently under clinical investigation for the treatment of Alzheimer's disease and progressive supranuclear palsy. It has a role as an EC 2.7.11.26 (tau-protein kinase) inhibitor, a neuroprotective agent, an anti-inflammatory agent and an apoptosis inducer. It is a member of naphthalenes, a member of benzenes and a thiadiazolidine.
Source Data Details
https://pubchem.ncbi.nlm.nih.gov/image/imagefly.cgi?cid=11313622&width=400&height=400
https://pubchem.ncbi.nlm.nih.gov/image/imagefly.cgi?cid=11313622&width=400&height=400