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National Institute of Allergy and Infectious Disease
NIH 3D
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NIH3D

Tideglusib

PubChem 11313622
was used by NIH 3D workflows to automatically generate models for
nevitdilmen
Created:
2/19/18
Submitted:
10/7/26
Published:
10/7/26
ball-and-stick, color, print caution
11313622-bas-color-print_cautionAtoms shown as ball-and-stick (geometry appears faceted on screen; apply smooth normals in Blender or similar to improve visualization; generally smooth when 3D printed) with standard colors. 3D printable, with caution, using certain 3D printers.

Select an image below to view

ball-and-stick, color, print cautionball-and-stick, no color, NIH 3D repairedthin sticks, colorthin sticks, no colorthick sticks, color, print cautionthick sticks, no color, NIH 3D repairedspace-filled, color, print cautionspace-filled, no color, NIH 3D repaired

Learn more about NIH 3D workflow outputs

3DPX-008687

NIH 3D DOI:

https://doi.org/10.60705/3dpx/8687.3

Licensing:

CC-BY
How to cite this NIH 3D entry
271
22
Version 3

Category

Small Molecules
Small Molecules
Description
Tideglusib is a member of the class of thiadiazolidines that is 1,2,4-thiadiazolidine-3,5-dione which is substituted by a naphthalen-1-yl group at position 2 and by a benzyl group at position 4. It is a non-ATP competitive inhibitor of glycogen synthase kinase 3beta (GSK3beta) and has neuroprotective effects. Currently under clinical investigation for the treatment of Alzheimer's disease and progressive supranuclear palsy. It has a role as a neuroprotective agent, an anti-inflammatory agent, an apoptosis inducer and an EC 2.7.11.26 (tau-protein kinase) inhibitor. It is a member of benzenes, a member of naphthalenes and a thiadiazolidine.
Source Data Details
https://pubchem.ncbi.nlm.nih.gov/image/imagefly.cgi?cid=11313622&width=400&height=400