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National Institute of Allergy and Infectious Disease
NIH 3D
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NIH3D

2-Pyrrolidinol, 1-methyl-2-(3-pyridinyl)-

PubChem 432
was used by NIH 3D workflows to automatically generate models for
Jwoozy
Created:
5/31/17
Submitted:
10/6/26
Published:
10/7/26
ball-and-stick, color, print caution
432-bas-color-print_cautionAtoms shown as ball-and-stick (geometry appears faceted on screen; apply smooth normals in Blender or similar to improve visualization; generally smooth when 3D printed) with standard colors. 3D printable, with caution, using certain 3D printers.

Select an image below to view

ball-and-stick, color, print cautionball-and-stick, no color, NIH 3D repairedthin sticks, colorthin sticks, no colorthick sticks, color, print cautionthick sticks, no color, NIH 3D repairedspace-filled, color, print cautionspace-filled, no color, NIH 3D repaired

Learn more about NIH 3D workflow outputs

3DPX-005414

NIH 3D DOI:

https://doi.org/10.60705/3dpx/5414.3

Licensing:

Public Domain
How to cite this NIH 3D entry
230
17
Version 3

Category

Small Molecules
Small Molecules
Description
2-Hydroxynicotine is a metabolite of the degradation of Nicotine (Nicotine is an alkaloid found in the nightshade family of plants (Solanaceae), predominantly in tobacco, and in lower quantities in tomato, potato, eggplant (aubergine), and green pepper) via a 2'-hydroxylation reaction producing 2'-hydroxynicotine as an intermediate in the cytochrome P450 2A6 [EC 1. 14. 14. 1] catalyzed conversion of nicotine to 4-(methylamino)-1-(3-pyridyl)-1-butanone. 2'-Hydroxynicotine spontaneously yields nicotine-1'(2')-iminium ion, which is in equilibrium with 4-(methylamino)-1-(3-pyridyl)-1-butanone. About 10% of nicotine and metabolites is excreted as 4-oxo-4-(3-pyridyl)butanoate (keto acid) and 4-hydroxy-4-(3-pyridyl)butanoate (hydroxy acid) in the urine of smokers.
Source Data Details
https://pubchem.ncbi.nlm.nih.gov/image/imagefly.cgi?cid=432&width=400&height=400