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National Institute of Allergy and Infectious Disease
NIH 3D
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NIH3D

Niraparib

PubChem 24958200
was used by NIH 3D workflows to automatically generate models for
bdallast
Created:
3/30/16
Submitted:
10/6/26
Published:
10/6/26
ball-and-stick, color, print caution
24958200-bas-color-print_cautionAtoms shown as ball-and-stick (geometry appears faceted on screen; apply smooth normals in Blender or similar to improve visualization; generally smooth when 3D printed) with standard colors. 3D printable, with caution, using certain 3D printers.

Select an image below to view

ball-and-stick, color, print cautionball-and-stick, no color, NIH 3D repairedthin sticks, colorthin sticks, no colorthick sticks, color, print cautionthick sticks, no color, NIH 3D repairedspace-filled, color, print cautionspace-filled, no color, NIH 3D repaired

Learn more about NIH 3D workflow outputs

3DPX-003144

NIH 3D DOI:

https://doi.org/10.60705/3dpx/3144.3

Licensing:

Public Domain
How to cite this NIH 3D entry
192
18
Version 3

Category

Small Molecules
Small Molecules
Description
Niraparib is a 2-[4-(piperidin-3-yl)phenyl]-2H-indazole-7-carboxamide that has S-configuration. It is a potent inhibitor of PARP1 and PARP2 (IC50 of 3.8 and 2.1 nM, respectively) and approved as a first-line maintenance treatment for women with advanced ovarian cancer after responding to platinum-based chemotherapy. It has a role as a radiosensitizing agent, an antineoplastic agent, an EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor and an apoptosis inducer.
Source Data Details
https://pubchem.ncbi.nlm.nih.gov/image/imagefly.cgi?cid=24958200&width=400&height=400