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National Institute of Allergy and Infectious Disease
NIH 3D
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NIH3D

Niraparib

PubChem 24958200
was used by NIH 3D workflows to automatically generate models for
bdallast
Created:
3/30/16
Submitted:
3/6/23
Published:
3/6/23
ball and stick, print caution
24958200-bas-color-print_NIH3DAtoms shown as ball-and-stick with standard colors. 3D printable, with caution, using certain 3D printers.

Select an image below to view

ball and stick, print cautionsticks, not intended for 3D printingsticks, not intended for 3D printingsticks, print cautionspace-filled, print cautionball and stick, print cautionspace-filled, print cautionsticks, print caution
3DPX-003144

NIH 3D DOI:

https://doi.org/10.60705/3dpx/3144.2

Licensing:

Public Domain
How to cite this NIH 3D entry
42
1
Version 2

Category

Small Molecules
Small Molecules
Description
Niraparib is a 2-[4-(piperidin-3-yl)phenyl]-2H-indazole-7-carboxamide that has S-configuration. It is a potent inhibitor of PARP1 and PARP2 (IC50 of 3.8 and 2.1 nM, respectively) and approved as a first-line maintenance treatment for women with advanced ovarian cancer after responding to platinum-based chemotherapy. It has a role as an antineoplastic agent, an EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor, a radiosensitizing agent and an apoptosis inducer.
Source Data Details
https://pubchem.ncbi.nlm.nih.gov/image/imagefly.cgi?cid=24958200&width=400&height=400
https://pubchem.ncbi.nlm.nih.gov/image/imagefly.cgi?cid=24958200&width=400&height=400