MTERF4-NSUN4 complex
Generated by NIH 3D workflows using data provided by
martinhallberg
Created:
6/26/14
Submitted:
3/6/23
Published:
3/6/23
4FP9-AB-ribbon-secondary-vis_NIH3DRibbon representation colored by secondary structure (a-helix: blue, B-sheet: red, coil: yellow). Not intended for 3D Printing.
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Description
This is a structure of the complex between human MTERF4 and NSUN4. In the structure, MTERF4 is shown to be composed of a series of MTERF-motifs poised to bind nucleic acid. The RNA m5C-methyltransferase NSUN4 lack a separate RNA binding domain commonly used for RNA recognition by related RNA methyltransferases. Instead, NSUN4 binds to the C-terminus of MTERF4. Hence, NSUN4 utilizes MTERF4 for RNA substrate recognition.
Please see:
Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15253-8.
Structure of the human MTERF4-NSUN4 protein complex that regulates mitochondrial ribosome biogenesis.
Spåhr H, Habermann B, Gustafsson CM, Larsson NG, Hallberg BM.